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Article

Altering chemosensitivity by modulating translation elongation.

PloS one - 1 Jan 2009

Robert Francis, Carrier Marilyn, Rawe Svea, Chen Samuel, Lowe Scott, Pelletier Jerry

Abstract excerpt

BACKGROUND: The process of translation occurs at a nexus point downstream of a number of signal pathways and developmental processes. Modeling activation of the PTEN/AKT/mTOR pathway in the Emu-Myc mouse is a valuable tool to study tumor genotype/chemosensitivity relationships in vivo. In this model, blocking translation initiation with silvestrol, an inhibitor of the ribosome recruitment step has been showed to...

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Source

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Identifiers

PMID: 19412536
DOI: 10.1371/journal.pone.0005428
PMCID: PMC2671598

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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