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Combination of hotspot mutations with methylation and fragmentomic profiles to enhance Multi-Cancer Early Detection

2024-08-19

Abstract excerpt

<h4>Background: </h4> Multi-cancer early detection (MCED) through a single blood test significantly advances cancer diagnosis. However, most MCED tests rely on a single type of biomarkers, leading to limited sensitivity, particularly for early-stage cancers. We previously developed SPOT-MAS, a multimodal ctDNA-based assay analyzing methylation and fragmentomic profiles to detect five common cancers. Despite its po...

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Literature Corpus work
9f1724e3-ca43-5d4e-bd3b-967bb20dc879
DOI
10.1101/2024.08.18.24312164
Open publication

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Combination of hotspot mutations with methylation and fragmentomic profiles to enhance Multi-Cancer Early DetectionDOI 10.1101/2024.08.18.24312164
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