Multimodal analysis of cell-free DNA to improve early detection of gastric cancer.

doi:10.1186/s12885-026-15720-0

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Multimodal analysis of cell-free DNA to improve early detection of gastric cancer.

BMC cancer - 23 Feb 2026

Long Vo Duy, Huynh Le Anh Khoa, Vo Dac Ho, Nguyen Thi Hue Hanh, Van Thi Tuong Vi, Nguyen Giang Thi Huong, Doan Thuy Nguyen, Nguyen Viet Hai, Tran Quang Dat, Dang Quang Thong, Nguyen Vu Tuan Anh, Ho Le Minh Quoc, Ha Thi Phuong Dung, Dang Thi Ngoc Dung, Nguyen Pham Thanh Nhan, Nguyen Khac Tien, Ho Van Chien, Le Thi Loc, Nguyen Thi Hong Nhung, Tu Ngoc Hieu, Tran Thanh Son, Jasmine Thanh Xuan, Vo Thi Loan, Nai Thi Huong Thoang, Tran Thuy Trang, Truong My Hoang, Tran Ngan Chau, Nguyen Thanh Cong, Nguyen Thi Truc, Le Bao Toan, Tang Van Phong, Nguyen Thi Tu, Nguyen Anh Tuan, Vu Hoang Giang, Van Phan Thi, Nguyen Thi Ngoc Tien, Cao Hoang Anh, Nguyen Trong Hieu, Tu Lan N, Giang Hoa, Phan Minh Duy, Nguyen Hoai-Nghia, Nguyen Van Thien Chi, Tran Le Son

Abstract excerpt

BACKGROUND: Gastric cancer remains a global health challenge due to the difficulty of detecting it early in asymptomatic, high-risk populations. Current invasive diagnostic methods are impractical for widespread screening. Liquid biopsy using circulating tumor DNA (ctDNA) shows promise, but early detection is hindered by the low abundance and heterogeneity of ctDNA. METHODS: We developed a multimodal cfDNA assay...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41731447
DOI: 10.1186/s12885-026-15720-0
PMCID: PMC13036984

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