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Combination of Hotspot Mutations With Methylation and Fragmentomic Profiles to Enhance Multi-Cancer Early Detection.

Cancer medicine - 1 Jan 2025

Nguyen Thi Hue Hanh, Vu Giang Hoang, Nguyen Tu Thi, Nguyen Tuan Anh, Tran Vu Uyen, Vu Luyen Thi, Nguyen Giang Thi Huong, Nguyen Nhat Duy, Tran Trung Hieu, Nguyen Van Thien Chi, Nguyen Thanh Dat, Nguyen Trong Hieu, Vo Dac Ho, Van Thi Tuong Vi, Do Thanh Thi, Le Minh Phong, Huynh Le Anh Khoa, Nguyen Duy Sinh, Tang Hung Sang, Nguyen Hoai-Nghia, Phan Minh-Duy, Giang Hoa, Tu Lan N, Tran Le Son

Abstract excerpt

BACKGROUND: Multi-cancer early detection (MCED) through a single blood test significantly advances cancer diagnosis. However, most MCED tests rely on a single type of biomarkers, leading to limited sensitivity, particularly for early-stage cancers. We previously developed SPOT-MAS, a multimodal ctDNA-based assay analyzing methylation and fragmentomic profiles to detect five common cancers. Despite its potential,...

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Biomarkers, Tumor
Circulating Tumor DNA
DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Early Detection of Cancer

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PMID: 39748775
DOI: 10.1002/cam4.70575
PMCID: PMC11695824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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