Article

Targeting a macrophage stemness factor to mitigate diseases post respiratory viral infection

2025-10-05

Abstract excerpt

Tissue-resident alveolar macrophages (AMs) rely on intrinsic stem-like programs for self-renewal and maintenance, yet the transcriptional networks that support these functions and their relevance to post-viral lung disease remain largely unknown. Here, we identify TCF4 ( Tcf7l2 ) as a critical transcription factor that governs AM maturation and stemness. Loss of TCF4 impaired AM proliferation, shifted their ident...

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Literature Corpus work: 9f11346d-39d8-5e1c-98c4-f31fa4c55d3b
DOI: 10.1101/2025.10.03.680366

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