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Article

IL-4-induced SOX9 confers lineage plasticity to aged adult lung stem cells

31 Jul 2024

Abstract excerpt

Wound healing in response to acute injury is mediated by the coordinated and transient activation of parenchymal, stromal, and immune cells that resolves to homeostasis. Environmental, genetic, and epigenetic factors associated with inflammation and aging can lead to persistent activation of the microenvironment and fibrosis. Here, we identify opposing roles of interleukin-4 (IL-4) cytokine signaling in...

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PMID: 39088319
DOI: 10.1016/j.celrep.2024.114569

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