Article

Single-cell atlas reveals alveolar macrophage-specific Oncostatin-M drives pulmonary fibrosis via fibroblast activation in PCV2d infection

2025-12-10

Abstract excerpt

A hallmark of pulmonary fibrosis is the aberrant activation of lung fibroblasts into pathological fibroblasts that produce excessive extracellular matrix(1). Clarifying the cell-specific mechanisms by which viruses induce this process is crucial for developing effective strategies to intervene in disease progression. Here, we demonstrate that alveolar macrophage subsets specifically express tumor suppressor M (Osm...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4c2304bd-d0d2-5085-a756-a9c441aa65da
DOI: 10.64898/2025.12.08.692949

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell atlas reveals alveolar macrophage-specific Oncostatin-M drives pulmonary fibrosis via fibroblast activation in PCV2d infectionDOI 10.64898/2025.12.08.692949Read

Integrative single-cell transcriptome analysis reveals new insights into post-COVID-19 pulmonary fibrosis and potential therapeutic targetsSemantic proximity Read

Activated interstitial macrophages are a predominant target of viral takeover and focus of inflammation in COVID-19 initiation in human lungSemantic proximity Read

SARS-CoV2 infection in whole lung primarily targets macrophages that display subset-specific responsesSemantic proximity Read

Non-canonical Oncostatin M Signaling Provides Protection during Respiratory Viral and Bacterial infectionsSemantic proximity Read

Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19Semantic proximity Read

Single-cell RNA-seq analysis reveals aberrant CSF1 expression in disease-causing synovial fibroblasts of pigmented villonodular synovitisSemantic proximity Read

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoVSemantic proximity Read

Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated responseSemantic proximity Read

Spatiotemporal landscape of SARS-CoV-2 pulmonary infection reveals Slamf9 + Spp1 + macrophages promoting viral clearance and inflammation resolutionSemantic proximity Read

Macrophage-derived SPP1 exacerbate myocardial injury by interacting with fibroblasts in viral myocarditisSemantic proximity Read

TNF Superfamily Member 14 Drives Post-Influenza Depletion of Alveolar Macrophages Enabling Secondary Pneumococcal PneumoniaSemantic proximity Read