Article

Biochemical reconstitutions reveal principles of human <i>γ</i> -TuRC assembly and function

2020-09-21

Abstract excerpt

The formation of cellular microtubule networks is regulated by the γ -tubulin ring complex ( γ -TuRC). This ∼2.3 MDa assembly of >31 proteins includes γ -tubulin and GCP2-6, as well as MZT1 and an actin-like protein in a “lumenal bridge”. The challenge of reconstituting the γ -TuRC has limited dissections of its assembly and function. Here, we report a complete biochemical reconstitution of the human γ -TuRC...

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Literature Corpus work: 9f043d6a-bbab-5aca-8dd3-5a6c414af8ad
DOI: 10.1101/2020.09.21.306845

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