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Reconstitution of Microtubule Nucleation In Vitro Reveals Novel Roles for Mzt1

1 Jul 2019

Abstract excerpt

Microtubule (MT) nucleation depends on the γ-tubulin complex (γ-TuC), in which multiple copies of the heterotetrameric γ-tubulin small complex (γ-TuSC) associate to form a ring-like structure (in metazoans, γ-tubulin ring complex; γ-TuRC) [1-7]. Additional conserved regulators of the γ-TuC include the small protein Mzt1 (MOZART1 in human; GIP1/1B and GIP2/1A in plants) [8-13] and proteins containing a Centrosomin...

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PMID: 31287970
DOI: 10.1016/j.cub.2019.05.058

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