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Article

The cryo-EM structure of a γ-TuSC elucidates architecture and regulation of minimal microtubule nucleation systems.

Nature communications - 11 Nov 2020

Zupa Erik, Zheng Anjun, Neuner Annett, Würtz Martin, Liu Peng, Böhler Anna, Schiebel Elmar, Pfeffer Stefan

Abstract excerpt

The nucleation of microtubules from αβ-tubulin subunits is mediated by γ-tubulin complexes, which vary in composition across organisms. Aiming to understand how de novo microtubule formation is achieved and regulated by a minimal microtubule nucleation system, we here determined the cryo-electron microscopy structure of the heterotetrameric γ-tubulin small complex (γ-TuSC) from C. albicans at near-atomic...

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Identifiers

PMID: 33177498
DOI: 10.1038/s41467-020-19456-8
PMCID: PMC7658347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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