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Article

A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein.

EMBO reports - 1 Feb 2006

D'Angelo Igor, Welti Stefan, Bonneau Fabien, Scheffzek Klaus

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a common tumour predisposition syndrome associated with numerous clinical complications. Mutations in the tumour suppressor gene NF1 are responsible for disease pathogenesis. This gene encodes the 320 kDa protein neurofibromin, the only clearly defined function of which is to act as a Ras-specific GTPase-activating protein (RasGAP). Here we report the structural discovery of a...

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Share to Crystallography, X-Ray
Share to Genes, Tumor Suppressor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16397625
DOI: 10.1038/sj.embor.7400602
PMCID: PMC1369252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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