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A Two-Tier Systems Medicine Model for Human Longevity: Restorative and Regenerative Pathways to the 120-Year Lifespan Potential

2025-12-12

Abstract excerpt

Modern geroscience and demographic data suggest that humans possess a biological lifespan potential of approximately 120 years, supported by evolutionary biology, longevity demographics, and cellular aging models. Yet global life expectancy in developed nations remains only 78–80 years—roughly a 20–30% shortfall. This gap is driven not by “inevitable aging” but by preventable chronic diseases rooted in metabolic,...

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Literature Corpus work
0f456fa9-9307-5c90-a70a-f975fe3b2ca7
DOI
10.20944/preprints202512.1191.v1
Open publication

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