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Article

A single factor for safer cellular rejuvenation

2025-06-06

Abstract excerpt

Ageing is a key driver of the major diseases afflicting the modern world. Slowing or reversing the ageing process would therefore drive significant and broad benefits to human health. Previously, the Yamanaka factors (OCT4, SOX2, KLF4, with or without c-MYC: OSK(M)) have been shown to rejuvenate cells based on accurate predictors of age known as epigenetic clocks. Unfortunately, OSK(M) induces dangerous pluripoten...

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Identifiers and source

Literature Corpus work
db995beb-4110-5391-8ed8-01643619bb06
DOI
10.1101/2025.06.05.657370
Open publication

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A single factor for safer cellular rejuvenationDOI 10.1101/2025.06.05.657370
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