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Article

A comprehensive approach to the molecular determinants of lifespan using a Boolean model of geroconversion

9 Sept 2016

Abstract excerpt

Altered molecular responses to insulin and growth factors (GF) are responsible for late-life shortening diseases such as type-2 diabetes mellitus (T2DM) and cancers. We have built a network of the signaling pathways that control S-phase entry and a specific type of senescence called geroconversion. We have translated this network into a Boolean model to study possible cell phenotype outcomes under diverse...

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PMID: 27613445
DOI: 10.1111/acel.12504

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