Article

Modeling the effects of EMT-immune dynamics on epithelial cancer progression

2019-04-26

Abstract excerpt

D uring progression from carcinoma in situ to an invasive tumor, the immune system is engaged in complex sets of interactions with various tumor cells. Tumor cell plasticity also alters disease trajectories via epithelial-to-mesenchymal transition (EMT). Several of the same pathways that regulate EMT are involved in tumor-immune interactions, yet little is known about the mechanisms and consequences of crosstalk b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e8726ca-242e-5330-b155-468d0b6638fb
DOI: 10.1101/615971

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modeling the effects of EMT-immune dynamics on epithelial cancer progressionDOI 10.1101/615971Read

Deciphering Epithelial–Mesenchymal Transition Regulatory Networks in Cancer through Computational ApproachesSemantic proximity Read

The pan-cancer landscape of crosstalk between epithelial-mesenchymal transition and immune evasion relevant to prognosis and immunotherapy responseSemantic proximity Read

Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysisSemantic proximity Read

Reconstructing disease dynamics for mechanistic insights and clinical benefitSemantic proximity Read

Immunological Consequences of Epithelial–Mesenchymal Transition in Tumor ProgressionSemantic proximity Read

Immunosuppressive Traits of the Hybrid Epithelial/Mesenchymal Phenotype.Semantic proximity Read

Modeling the dynamics of EMT reveals genes associated with pan-cancer intermediate states and plasticitySemantic proximity Read

Computational Identification of Migrating T cells in Spatial Transcriptomics DataSemantic proximity Read

Immunosuppressive traits of the hybrid epithelial/mesenchymal phenotypeSemantic proximity Read

Data‐ and theory‐driven approaches for understanding paths of epithelial–mesenchymal transitionSemantic proximity Read

Systems-level analysis identifies IRF6 as an inhibitor of epithelial-mesenchymal transitionSemantic proximity Read

Investigating epithelial‐mesenchymal heterogeneity of tumors and circulating tumor cells with transcriptomic analysis and biophysical modelingSemantic proximity Read