Article

Protein and DNA Conformational Changes Contribute to Specificity of Cre Recombinase

2024-12-11

Abstract excerpt

Cre, a conservative site-specific tyrosine recombinase, is a powerful gene editing tool in the laboratory. Expanded applications in human health are hindered by lack of understanding of the mechanism by which Cre selectively binds and recombines its cognate loxP sequences. This knowledge is essential for retargeting the enzyme to new sites and for mitigating effects of off-target recombination. Prior studies have...

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Literature Corpus work: 9e83f98f-6c13-59b9-b03d-4a6101ec41f2
DOI: 10.1101/2024.12.11.627928

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