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Thermodynamics of Indirect Readout in Cre- <i>loxP</i> Recognition

2026-05-08

Abstract excerpt

Cre, a site-specific tyrosine DNA recombinase, enables targeted manipulation of genetic material without production of cytotoxic double-strand DNA breaks. Though widely deployed in biotechnology, an incomplete understanding of how Cre recognizes its cognate loxP target limits its broader application in human health. Cre has been proposed to recognize an inverted pair of recombinase binding elements (RBEs) at lox...

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Literature Corpus work
18520b20-4755-5dad-b706-53d34e476cb6
DOI
10.64898/2026.05.05.721372
Open publication

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Thermodynamics of Indirect Readout in Cre- <i>loxP</i> RecognitionDOI 10.64898/2026.05.05.721372
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