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Article

Genetic variations within the ERE motif modulate plasticity and energetics of binding of DNA to the ERα nuclear receptor.

Archives of biochemistry and biophysics - 15 Mar 2011

Deegan Brian J, Bhat Vikas, Seldeen Kenneth L, McDonald Caleb B, Farooq Amjad

Abstract excerpt

Upon binding to estrogens, the ERα nuclear receptor acts as a transcription factor and mediates a multitude of cellular functions central to health and disease. Herein, using isothermal titration calorimetry (ITC) and circular dichroism (CD) in conjunction with molecular modeling (MM), we analyze the effect of symmetric introduction of single nucleotide variations within each half-site of the estrogen response...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21216218
DOI: 10.1016/j.abb.2011.01.002
PMCID: PMC3044919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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