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Article

African-specific molecular taxonomy of prostate cancer.

Nature - 1 Sept 2022

Jaratlerdsiri Weerachai, Jiang Jue, Gong Tingting, Patrick Sean M, Willet Cali, Chew Tracy, Lyons Ruth J, Haynes Anne-Maree, Pasqualim Gabriela, Louw Melanie, Kench James G, Campbell Raymond, Horvath Lisa G, Chan Eva K F, Wedge David C, Sadsad Rosemarie, Brum Ilma Simoni, Mutambirwa Shingai B A, Stricker Phillip D, Bornman M S Riana, Hayes Vanessa M

Abstract excerpt

Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry is a significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than global averages1. The contributing genetic and non-genetic factors, and associated mutational processes, are unknown2,3. Here, through whole-genome sequencing of treatment-naive prostate cancer samples from 183 ancestrally...

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Africa
Africa South of the Sahara
Black People
Ethnicity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prostatic Neoplasms

RNA, Long Noncoding

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Identifiers

PMID: 36045292
DOI: 10.1038/s41586-022-05154-6
PMCID: PMC9477733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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