Article
A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa.
Cancer research - 1 Jul 2020
Harlemon Maxine, Ajayi Olabode, Kachambwa Paidamoyo, Kim Michelle S, Simonti Corinne N, Quiver Melanie H, Petersen Desiree C, Mittal Anuradha, Fernandez Pedro W, Hsing Ann W, Baichoo Shakuntala, Agalliu Ilir, Jalloh Mohamed, Gueye Serigne M, Snyper Nana Yaa F, Adusei Ben, Mensah James E, Abrahams Afua O D, Adebiyi Akindele O, Orunmuyi Akin T, Aisuodionoe-Shadrach Oseremen I, Nwegbu Maxwell M, Joffe Maureen, Chen Wenlong C, Irusen Hayley, Neugut Alfred I, Quintana Yuri, Seutloali Moleboheng, Fadipe Mayowa B, Warren Christopher, Woehrmann Marcos H, Zhang Peng, Ongaco Chrissie M, Mawhinney Michelle, McBride Jo, Andrews Caroline V, Adams Marcia, Pugh Elizabeth, Rebbeck Timothy R, Petersen Lindsay N, Lachance Joseph
Abstract excerpt
Although prostate cancer is the leading cause of cancer mortality for African men, the vast majority of known disease associations have been detected in European study cohorts. Furthermore, most genome-wide association studies have used genotyping arrays that are hindered by SNP ascertainment bias. To overcome these disparities in genomic medicine, the Men of African Descent and Carcinoma of the Prostate (MADCaP)...
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