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Article

Prostate cancer genetic risk and associated aggressive disease in men of African ancestry.

Nature communications - 5 Dec 2023

Soh Pamela X Y, Mmekwa Naledi, Petersen Desiree C, Gheybi Kazzem, van Zyl Smit, Jiang Jue, Patrick Sean M, Campbell Raymond, Jaratlerdseri Weerachai, Mutambirwa Shingai B A, Bornman M S Riana, Hayes Vanessa M

Abstract excerpt

African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet, genetic studies have largely been conducted outside the context of Sub-Saharan Africa, identifying 278 common risk variants contributing to a multiethnic polygenic risk score, with rare variants focused on a panel of roughly 20 pathogenic genes. Based on this knowledge, we are unable to determine polygenic risk or...

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Identifiers

PMID: 38052806
DOI: 10.1038/s41467-023-43726-w
PMCID: PMC10697980

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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