Article

Induced pluripotent stem cell-derived dendritic cell vaccine therapy genetically modified on the ubiquitin-proteasome system

2022-08-22

Abstract excerpt

We previously reported that dendritic cells (DCs) transduced with the full-length tumor-associated antigen (TAA) gene induced TAA-specific cytotoxic T lymphocytes (CTLs) to elicit antitumor responses. To overcome the issue of quantity and quality of DCs required for DC vaccine therapy, we focused on induced pluripotent stem cells (iPSCs) as a new tool for obtaining DCs and reported efficacy of iPSCs-derived DCs (i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e73729f-ab7b-5fa1-b230-ecab5420f0af
DOI: 10.21203/rs.3.rs-1821680/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Induced pluripotent stem cell-derived dendritic cell vaccine therapy genetically modified on the ubiquitin-proteasome systemDOI 10.21203/rs.3.rs-1821680/v1Read

Induced Pluripotent Stem Cells: Challenges and Opportunities for Cancer ImmunotherapySemantic proximity Read

Tumor RNA-Transfected Dendritic Cells Generated From Induced Pluripotent Stem Cells Induces Anti-Tumor ImmunitySemantic proximity Read

Induced Pluripotent Stem Cell (iPSC)–Derived Lymphocytes for Adoptive Cell Immunotherapy: Recent Advances and ChallengesSemantic proximity Read

Induced Pluripotent Stem Cell-Based Cancer Immunotherapy: Strategies and PerspectivesSemantic proximity Read

‘Off the shelf’ immunotherapies: Generation and application of pluripotent stem cell‐derived immune cellsSemantic proximity Read

Characterization of dendritic cells and macrophages generated by directed differentiation from mouse induced pluripotent stem cells.Semantic proximity Read

In situ delivery of iPSC-derived dendritic cells with local radiotherapy generates systemic antitumor immunity and potentiates PD-L1 blockade in preclinical poorly immunogenic tumor models.Semantic proximity Read

Tumor RNA transfected DCs derived from iPS cells elicit cytotoxicity against cancer cells induced from colorectal cancer patients in vitroSemantic proximity Read

Mesothelin-Specific T Cell Cytotoxicity Against Triple Negative Breast Cancer Is Enhanced By 40s Ribosomal Protein Subunit 3-Treated Self-Differentiated Dendritic CellsSemantic proximity Read

Gene-modified dendritic cell vaccines for cancer.Semantic proximity Read

Generation of mouse pluripotent stem cell-derived proliferating myeloid cells as an unlimited source of functional antigen-presenting cells.Semantic proximity Read

Regeneration of Tumor-Antigen-Specific Cytotoxic T Lymphocytes from iPSCs Transduced with Exogenous TCR GenesSemantic proximity Read