Generation of mouse pluripotent stem cell-derived proliferating myeloid cells as an unlimited source of functional antigen-presenting cells.

doi:10.1158/2326-6066.CIR-14-0117

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Generation of mouse pluripotent stem cell-derived proliferating myeloid cells as an unlimited source of functional antigen-presenting cells.

Cancer immunology research - 1 Jun 2015

Zhang Rong, Liu Tian-Yi, Senju Satoru, Haruta Miwa, Hirosawa Narumi, Suzuki Motoharu, Tatsumi Minako, Ueda Norihiro, Maki Hiroyuki, Nakatsuka Ryusuke, Matsuoka Yoshikazu, Sasaki Yutaka, Tsuzuki Shinobu, Nakanishi Hayao, Araki Ryoko, Abe Masumi, Akatsuka Yoshiki, Sakamoto Yasushi, Sonoda Yoshiaki, Nishimura Yasuharu, Kuzushima Kiyotaka, Uemura Yasushi

Abstract excerpt

The use of dendritic cells (DC) to prime tumor-associated antigen-specific T-cell responses provides a promising approach to cancer immunotherapy. Embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) can differentiate into functional DCs, thus providing an unlimited source of DCs. However, the previously established methods of generating practical volumes of DCs from pluripotent stem cells (PSC)...

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PMID: 25672396
DOI: 10.1158/2326-6066.CIR-14-0117

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