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Induced Pluripotent Stem Cells: Challenges and Opportunities for Cancer Immunotherapy

17 Apr 2014

Abstract excerpt

Despite recent advances in cancer treatment over the past 30 years, therapeutic options remain limited and do not always offer a cure for malignancy. Given that tumor-associated antigens (TAA) are, by definition, self-proteins, the need to productively engage autoreactive T cells remains at the heart of strategies for cancer immunotherapy. These have traditionally focused on the administration of autologous...

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PMID: 24860566
DOI: 10.3389/fimmu.2014.00176

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