Article

Mesothelin-Specific T Cell Cytotoxicity Against Triple Negative Breast Cancer Is Enhanced By 40s Ribosomal Protein Subunit 3-Treated Self-Differentiated Dendritic Cells

2022-01-03

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose</bold> Triple negative breast cancer (TNBC) is deficient in targeted treatment resulting in poor prognosis. Targeting overexpressed mesothelin (MSLN) using MSLN-specific T cells is an attractive treatment approach.<bold>Methods</bold> The immunohistochemistry of MSLN in TNBC tissues were performed. A lentiviral vector harboring granulocyte-macrophage colony stimulating fac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 19f89e03-799b-5208-bcb6-d5d88ccbfa1e
DOI: 10.21203/rs.3.rs-1165739/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mesothelin-Specific T Cell Cytotoxicity Against Triple Negative Breast Cancer Is Enhanced By 40s Ribosomal Protein Subunit 3-Treated Self-Differentiated Dendritic CellsDOI 10.21203/rs.3.rs-1165739/v1Read

Mesothelin- and nucleolin-specific T cells from combined short peptides effectively kill triple-negative breast cancer cellsSemantic proximity Read

Macrophages expressing chimeric cytokine receptors have an inflammatory phenotype and anti-tumoral activity upon IL-10 or TGFβ stimulationSemantic proximity Read

Enhancing HLA-DR in Cytotoxic T Lymphocytes is crucial for the development of efficient adoptive T cell Therapies for Breast CancerSemantic proximity Read

Rewiring dendritic cell function with CLEC9A and DEC205-based chimeric antigen receptorsSemantic proximity Read

Targeting cancer-associated adipocyte-derived CXCL8 inhibits triple-negative breast cancer progression and enhances the efficacy of anti-PD-1 immunotherapySemantic proximity Read

Differential PML localization in tumor-associated macrophages reflects the inflammatory state and the prognosis of triple-negative breast cancer patientsSemantic proximity Read

Advancing pancreatic cancer therapy by mesothelin-specific nanobody conjugationSemantic proximity Read

Cd73-LNPs promotes antitumor T-cell immunity via amplifying Tlr3-mediated immunostimulatory dendritic cell activationSemantic proximity Read

MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancerSemantic proximity Read

Toll-Like Receptor 2 Promotes Breast Cancer Progression and Resistance to ChemotherapySemantic proximity Read

High immunogenic potential of p53 mRNA-transfected dendritic cells in patients with primary breast cancerSemantic proximity Read

Development of 3D breast cancer models with human T cells expressing engineered MAIT cell receptorsSemantic proximity Read