Article

Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction

2022-11-24

Abstract excerpt

Clinically serious congenital heart valve defects arise from improper growth and remodeling of endocardial cushions into leaflets. Genetic mutations have been extensively studied but explain less than 20% of cases. Mechanical forces generated by beating hearts drive valve development, but how these forces collectively determine valve growth and remodeling remains incompletely understood. Here we decouple the influ...

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Identifiers and source

Literature Corpus work: 9e6e1973-de0a-566b-b2e5-906ccbeeb315
DOI: 10.1101/2022.11.24.517814

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