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Article

Hydrostatic mechanical stress regulates growth and maturation of the atrioventricular valve.

Development (Cambridge, England) - 1 Jul 2021

Bassen David, Wang Mingkun, Pham Duc, Sun Shuofei, Rao Rashmi, Singh Rishabh, Butcher Jonathan

Abstract excerpt

During valvulogenesis, cytoskeletal, secretory and transcriptional events drive endocardial cushion growth and remodeling into thin fibrous leaflets. Genetic disorders play an important role in understanding valve malformations but only account for a minority of clinical cases. Mechanical forces are ever present, but how they coordinate molecular and cellular decisions remains unclear. In this study, we used...

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Source

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Identifiers

PMID: 34086041
DOI: 10.1242/dev.196519
PMCID: PMC8276982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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