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Article

Mechano-potential etiologies of aortic valve disease.

Journal of biomechanics - 5 Jan 2010

David Merryman W

Abstract excerpt

Aortic valve leaflets experience varying applied loads during the cardiac cycle. These varying loads act on both cell types of the leaflets, endothelial and interstitial cells, and cause molecular signaling events that are required for repairing the leaflet tissue, which is continually damaged from the applied loads. However, with increasing age, this reparative mechanism appears to go awry as valve interstitial...

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Identifiers

PMID: 19811785
DOI: 10.1016/j.jbiomech.2009.09.013
PMCID: PMC2813414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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