Article

Single RNA molecule resolution spatial imaging of immunotherapy response in triple negative breast tumors harboring tertiary lymphoid structures

2024-03-22

Abstract excerpt

<h4>Summary</h4> Cancer immunotherapy trials have had variable success, prompting a search for biomarkers of response. Tertiary lymphoid structures (TLS) have emerged as prognostic for multiple tumor types. These ectopic immunological bodies resemble secondary lymphoid organs with segregated B and T cell zones, but they are heterogeneous in their organization and cellular composition. These features have conseque...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e54400e-5214-54fb-944b-65890a1ee6e6
DOI: 10.1101/2024.03.19.585798

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single RNA molecule resolution spatial imaging of immunotherapy response in triple negative breast tumors harboring tertiary lymphoid structuresDOI 10.1101/2024.03.19.585798Read

Characterizing tertiary lymphoid structures associated single-cell atlas in breast cancer patientsSemantic proximity Read

The atlas of the tertiary lymphoid structure with omics data from breast cancer patientsSemantic proximity Read

Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibitionSemantic proximity Read

A High-Dimensional Window into the Micro-Environment of Triple Negative Breast CancerSemantic proximity Read

Robust biomarker discovery through multiplatform multiplex image analysis of breast cancer clinical cohortsSemantic proximity Read

Single Cell Spatial Analysis and Biomarker Discovery in Hodgkin LymphomaSemantic proximity Read

Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasisSemantic proximity Read

Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application.Semantic proximity Read

Spatial multi-omics reveal intratumoral humoral immunity niches associated with tertiary lymphoid structures in pancreatic cancer immunotherapy pathologic respondersSemantic proximity Read

Identification and characterization of tertiary lymphoid structures in brain metastasesSemantic proximity Read

Analysis of intratumoral immune heterogeneity reveals spatial organisation of immunosuppression in breast cancerSemantic proximity Read

Integrative Spatial Analysis of H&E and IHC Images Identifies Prognostic Immune Subtypes Correlated with Progression-Free Survival in Human Papillomavirus (HPV)-Related Oropharyngeal Squamous Cell CarcinomaSemantic proximity Read