Article

Robust biomarker discovery through multiplatform multiplex image analysis of breast cancer clinical cohorts

2023-02-03

Abstract excerpt

<h4> A bstract </h4> Spatial profiling of tissues promises to elucidate tumor-microenvironment interactions and enable development of spatial biomarkers to predict patient response to immunotherapy and other therapeutics. However, spatial biomarker discovery is often carried out on a single patient cohort or imaging technology, limiting statistical power and increasing the likelihood of technical artifacts. In...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 262d56ba-97df-5f44-a3b7-e1ea9005c305
DOI: 10.1101/2023.01.31.525753

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Robust biomarker discovery through multiplatform multiplex image analysis of breast cancer clinical cohortsDOI 10.1101/2023.01.31.525753Read

Multiplex Immunohistochemistry and High-Throughput Image Analysis for Evaluation of Spatial Tumor Immune Cell Markers in Human Breast Cancer: Preliminary Results from the Nashville Breast Health StudySemantic proximity Read

LOCATOR: feature extraction and spatial analysis of the cancer tissue microenvironment using mass cytometry imaging technologiesSemantic proximity Read

Intra-tumoral spatial heterogeneity in breast cancer quantified using high-dimensional protein multiplexing and single cell phenotypingSemantic proximity Read

The single-cell pathology landscape of breast cancer.Semantic proximity Read

A High-Dimensional Window into the Micro-Environment of Triple Negative Breast CancerSemantic proximity Read

Spatial Single-Cell Transcriptomic Analysis in Breast Cancer Reveals Potential Biomarkers for PD1 Blockade TherapySemantic proximity Read

Multiplexed Imaging Analysis of the Tumor-Immune Microenvironment Reveals Predictors of Outcome in Triple-Negative Breast CancerSemantic proximity Read

Breast cancer through the lens of whole transcriptome spatial imagingSemantic proximity Read

Spatial organization of the tumor-immune microenvironment in ER-positive breast cancer: remodeling during treatment and associations with clinical responseSemantic proximity Read

Single RNA molecule resolution spatial imaging of immunotherapy response in triple negative breast tumors harboring tertiary lymphoid structuresSemantic proximity Read

Multiplexed Imaging Analysis of the Tumor-Immune Microenvironment Reveals Predictors of Outcome in Triple-Negative Breast CancerSemantic proximity Read

Breast tumor microenvironment structures are associated with genomic features and clinical outcomeSemantic proximity Read