Article

POLR2A Drives Tumor Cell Aggressive in Both VHL and PBRM1 Mutation Renal-Cell Carcinoma

2021-11-03

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Loss of <italic>VHL </italic>always results in the loss of <italic>PBRM1 </italic>and causes aggressive clear cell renal cell carcinoma. However, <italic>VHL</italic> mutation was not significantly associated with worse survival, and PBRM1 modulate the tumor behavior is not clear. Thus, exploration of key molecules promoting the tumor aggressive is urgent in bot...

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Literature Corpus work: 9e32dd99-d5d0-59d5-9e2d-fb47a189fd51
DOI: 10.21203/rs.3.rs-1039666/v1

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