Article

Upregulation of Pole2 Promotes Clear Cell Renal Cell Carcinoma Progression via AKT/mTOR Pathway and Predicts a Poor Prognosis

2020-06-22

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Pole2 gene is a subunit of DNA polymerases localized in the nucleus, which commonly present in DNA repair. The effect of pole2 in renal cell carcinoma (RCC) still remain unclear. Here we investigate its clinical significance, function in RCC cells and possible mechanism of effect.<bold>Methods:</bold> Using TCGA database, we identified that up-regulation of pole...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2000cfbc-a4e1-5a56-a351-93e7ad9cc0d3
DOI: 10.21203/rs.3.rs-35733/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Upregulation of Pole2 Promotes Clear Cell Renal Cell Carcinoma Progression via AKT/mTOR Pathway and Predicts a Poor PrognosisDOI 10.21203/rs.3.rs-35733/v1Read

POLR2A Drives Tumor Cell Aggressive in Both VHL and PBRM1 Mutation Renal-Cell CarcinomaSemantic proximity Read

KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathwaySemantic proximity Read

BAP1 serves as a clear-cell renal cell carcinoma suppressor and is inversely regulated by miR-200c-3pSemantic proximity Read

UBE2C contributes to malignant phenotypes in clear cell renal cell carcinoma via cell cycle and apoptosis regulation.Semantic proximity Read

TAGLN2 promotes the proliferation, migration, invasion and EMT of renal clear cell carcinoma through PI3K/Akt signaling pathwaySemantic proximity Read

CHPF boosts proliferation and invasion of clear cell renal cell carcinomaSemantic proximity Read

Overexpression of PLCG2 and TMEM38A inhibit tumor progression in clear cell renal cell carcinomaSemantic proximity Read

Loss of CDCA5 Promotes Cell Apoptosis by Activating the DNA Damage Response in Clear Cell Renal Cell CarcinomaSemantic proximity Read

Knockdown of long non-coding RNA PVT1 induces apoptosis and cell cycle arrest in clear cell renal cell carcinoma through the epidermal growth factor receptor pathwaySemantic proximity Read

MCM2-7 in Clear Cell Renal Cell Carcinoma: MCM7 Promotes Tumor Cell ProliferationSemantic proximity Read

Comprehensive Analysis of the Expression and Prognosis for <i>PSMBs</i> in Clear Cell Renal Cell CarcinomaSemantic proximity Read

MiR-182-5p Inhibits the Tumorigenesis of clear cell renal cell carcinoma by Repressing UBE2TSemantic proximity Read