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Significance of PBRM1 mutation in disease progress and drug selection in clear cell renal cell carcinoma.

Biotechnology & genetic engineering reviews - 1 Dec 2024

He Donghua, Ma Tianyan, Yi Ni, Zhang Sijie, Ding Guanxiong

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is the predominant type of kidney cancer, and the mutation of PBRM1 (Polybromo 1) gene is a commonly observed genetic alteration. The high frequency of PBRM1 mutation in ccRCC suggests its potential use as a biomarker for personalized therapy. In this study, we aimed to investigate the significance of PBRM1 mutation in disease progression and drug sensitivity in ccRCC....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37079762
DOI: 10.1080/02648725.2023.2204692

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