Article

The conformational heterogeneity of the tumor suppressor p53 is tuned by punctual mutations

2022-07-19

Abstract excerpt

Conformational heterogeneity of the p53 tumor suppressor, wild-type and mutated forms, was investigated by computational modelling combined with all atoms Molecular Dynamics (MD) simulations. Four different punctual mutations (p53R175H, p53R248Q, p53R273H, p53R282W), which are known to affect the DNA binding and belong to the most frequent hot-spot mutations in human cancers, were taken into consideration. The MD...

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Literature Corpus work: 9e015674-d3e0-5753-a14a-57dac50c11d4
DOI: 10.22541/au.165823624.46566431/v1

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