Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels.

doi:10.1371/journal.pone.0122629

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Article

Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels.

PloS one - 1 Jan 2015

Xu Yan, Furutani Shogo, Ihara Makoto, Ling Yun, Yang Xinling, Kai Kenji, Hayashi Hideo, Matsuda Kazuhiko

Abstract excerpt

Meroterpenoid chrodrimanins, produced from Talaromyces sp. YO-2, are known to paralyze silkworm (Bombyx mori) larvae, but their target is unknown. We have investigated the actions of chrodrimanin B on ligand-gated ion channels of silkworm larval neurons using patch-clamp electrophysiology. Chrodrimanin B had no effect on membrane currents when tested alone at 1 μM. However, it completely blocked the...

Topics

Animals
Bombyx
Chloride Channels
Dose-Response Relationship, Drug
GABA Antagonists
Humans
Insect Proteins
Insecticides
Ion Channel Gating
Larva
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurons

Oocytes

Polyketides

Pyrazoles

Receptors, GABA

Safety

Sesquiterpenes

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Identifiers

PMID: 25902139
DOI: 10.1371/journal.pone.0122629
PMCID: PMC4406737

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