Article

Thalamus–cortex interactions drive cell type-specific cortical development in human pluripotent stem cell-derived assembloids

2025-10-12

Abstract excerpt

The thalamus plays a pivotal role in the development and function of neural circuits in the cerebral cortex. However, how thalamus–cortex interactions influence human cortical development remains unknown primarily because of the inaccessibility of the human embryonic brain. Here, we demonstrate thalamus-dependent gene expression, circuit organization, and neural activity during corticogenesis using human thalamoco...

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Literature Corpus work: 9dd12a36-103d-504b-a1a6-bc9a347b392b
DOI: 10.1101/2025.10.11.681772

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