Article
Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders.
Cell stem cell - 7 Mar 2024
Shin David, Kim Chang N, Ross Jayden, Hennick Kelsey M, Wu Sih-Rong, Paranjape Neha, Leonard Rachel, Wang Jerrick C, Keefe Matthew G, Pavlovic Bryan J, Donohue Kevin C, Moreau Clara, Wigdor Emilie M, Larson H Hanh, Allen Denise E, Cadwell Cathryn R, Bhaduri Aparna, Popova Galina, Bearden Carrie E, Pollen Alex A, Jacquemont Sebastien, Sanders Stephan J, Haussler David, Wiita Arun P, Frost Nicholas A, Sohal Vikaas S, Nowakowski Tomasz J
Abstract excerpt
Thalamic dysfunction has been implicated in multiple psychiatric disorders. We sought to study the mechanisms by which abnormalities emerge in the context of the 22q11.2 microdeletion, which confers significant genetic risk for psychiatric disorders. We investigated early stages of human thalamus development using human pluripotent stem cell-derived organoids and show that the 22q11.2 microdeletion underlies...
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