Article

Thalamic NRXN1-Mediated Input to Human Cortical Progenitors Drives Upper Layer Neurogenesis

2025-04-25

Abstract excerpt

According to the protocortex hypothesis, extrinsic thalamic signaling is necessary for refining cortical areas and cell types, but the mechanism by which these inputs shape the development and expansion of the human cortex remains largely unexplored. We fuse cortical and thalamic organoids to study this process. Using single-nuclei RNA-sequencing and cellular imaging, we discover that thalamic signals during a cri...

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Literature Corpus work: 1ffb7639-01bb-573d-84d1-702d02573cfe
DOI: 10.1101/2025.04.25.650717

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