Article

Progranulin in the Nucleus Accumbens Contributes to Neuroinflammation-Induced Depression-Like Behavior in Mice

2022-09-16

Abstract excerpt

<h4>Background: </h4> Neuroinflammation in the nucleus accumbens (NAc) is well known to influence the progression of depression. However, the molecular mechanisms triggering NAc neuroinflammation in depression have not been fully elucidated. Progranulin (PGRN) is a multifunctional growth factor that is linked to the innate immune response and inflammation, and PGRN plays a key role in neurodegenerative diseases. H...

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Literature Corpus work: 9dceb035-088c-5dca-b902-1cbcf6228bba
DOI: 10.21203/rs.3.rs-2060518/v1

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