Whole‐transcriptome sequencing identifies neuroinflammation, metabolism and blood–brain barrier related processes in the hippocampus of aged mice during perioperative period

Abstract excerpt

AIM: Perioperative neurocognitive disorders (PND) occur frequently after surgery and anesthesia, especially in aged patients. Previous studies have shown multiple PND related mechanisms in the hippocampus; however, their relationships remain unclear. Meanwhile, the perioperative neuropathological processes are sophisticated and changeable, single period study could not reveal the accurate mechanisms. Thus,...

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