Article

Integrative Transcriptomic and Machine Learning Analysis Reveals a Robust Gene Signature in Parkinson’s Disease

2026-02-06

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss in the substantia nigra and the accumulation of misfolded α-synuclein, leading to motor and non-motor symptoms. Early and accurate diagnosis remains challenging due to the gradual onset of symptoms and disease heterogeneity. In this study, we combined brain-region–specific tran...

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Literature Corpus work: b42dc04c-a116-5e1a-9a67-87e9d78ab8ac
DOI: 10.21203/rs.3.rs-8799127/v1

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