Article

Endothelial cell Nrf2 controls neuroinflammation following a systemic insult

2024-10-22

Abstract excerpt

<h4>Summary</h4> Systemic inflammation can lead to neuroinflammation with acute consequences such as delirium and long-lasting deleterious effects including cognitive decline and the exacerbation of neurodegenerative disease progression. Here we show that transcription factor Nrf2 controls brain endothelial cell homeostasis and barrier strength. We found that peripheral inflammation caused infiltration of macroph...

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Literature Corpus work: 9d70ed81-86c6-56ba-b4f6-969d59c7d4bb
DOI: 10.1101/2024.10.21.619507

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