Article

Nrf2 controls homeostatic transcriptional signatures and inflammatory responses in a cell-type specific manner in the adult mouse brain

2024-11-14

Abstract excerpt

Nrf2 is an attractive potential therapeutic target for various neurological disorders including neurodegenerative diseases. The mechanisms behind Nrf2-mediated cytoprotection are incompletely understood, however, an anti-inflammatory effect is a popular hypothesis, based primarily on studies where the prior pharmacological activation of Nrf2 has suppressed subsequent responses to inflammatory insults. In the adult...

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Literature Corpus work: 12e6da6c-488f-58e0-b720-526792fe4217
DOI: 10.1101/2024.11.14.623657

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