Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.

doi:10.1093/gerona/glx177

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Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.

The journals of gerontology. Series A, Biological sciences and medical sciences - 14 Jun 2018

Tarantini Stefano, Valcarcel-Ares M Noa, Yabluchanskiy Andriy, Tucsek Zsuzsanna, Hertelendy Peter, Kiss Tamas, Gautam Tripti, Zhang Xin A, Sonntag William E, de Cabo Rafael, Farkas Eszter, Elliott Michael H, Kinter Michael T, Deak Ferenc, Ungvari Zoltan, Csiszar Anna

Abstract excerpt

Obesity has deleterious effects on cognitive function in the elderly adults. In mice, aging exacerbates obesity-induced oxidative stress, microvascular dysfunction, blood-brain barrier (BBB) disruption, and neuroinflammation, which compromise cognitive health. However, the specific mechanisms through which aging and obesity interact to remain elusive. Previously, we have shown that Nrf2 signaling plays a critical...

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PMID: 29905772
DOI: 10.1093/gerona/glx177
PMCID: PMC6001893

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