Article

Stiffness-dependent LOX regulation via HIF-1 drives extracellular matrix modifications in psoriasis

2024-05-14

Abstract excerpt

Psoriasis is a common chronic inflammatory skin disease characterized by a thickened epidermis with elongated rete ridges and massive inflammatory immune cell infiltration. It is currently unclear what impact mechanoregulatory aspects in the dermis may have on disease progression. Using multiphoton second harmonic generation microscopy we found that the extracellular matrix (ECM) was profoundly reorganized within...

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Literature Corpus work: 9d5b5870-c743-58ee-b15b-ff10c8cd52fd
DOI: 10.1101/2024.05.14.594058

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