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Article

Exploring the causal effects of serum lipids and lipidomes on lewy body dementia: a Mendelian randomization study.

Frontiers in endocrinology - 1 Jan 2024

Fu Qingan, Pan Guanrui, Yu Qingyun, Liu Zhekang, Shen Tianzhou, Ma Xiaowei, Jiang Long

Abstract excerpt

Background: Lewy body dementia (LBD) is a neurodegenerative disorder characterized by the accumulation of Lewy bodies, which primarily composed of misfolded alpha-synuclein (αS). The development of LBD and APOE4 subtypes is thought to be associated with disorders of lipid metabolism. In this study, we investigated the causal relationship between serum lipids, liposomes and LBD using a two-sample Mendelian...

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Apolipoprotein E4
Genome-Wide Association Study
Lewy Body Disease
Lipid Metabolism
Lipidomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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Identifiers

PMID: 39363901
DOI: 10.3389/fendo.2024.1456005
PMCID: PMC11446761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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