Article

Quantitative dose-response analysis untangles host bottlenecks to enteric infection

2022-10-12

Abstract excerpt

Host bottlenecks prevent many infections before the onset of disease by eliminating invading pathogens. Monitoring the diversity of a barcoded population of the diarrhea causing bacterium Citrobacter rodentium during colonization of its natural host, mice, allowed us to determine the number of cells that found the infection by establishing a replicative niche. The size of the pathogen’s founding population scaled...

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Literature Corpus work: 9d3b4f5f-5c2c-5f06-94f4-1700c4c7c1bb
DOI: 10.1101/2022.10.11.511778

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