Article

Gastric acid and escape to systemic circulation represent major bottlenecks to host infection by Citrobacter rodentium

2022-09-24

Abstract excerpt

Abstract The gastrointestinal (GI) environment plays a critical role in shaping enteric infections. Host environmental factors create bottlenecks, restrictive events that reduce the genetic diversity of invading bacterial populations. However, the identity and impact of bottleneck events on bacterial infection are largely unknown. We used Citrobacter rodentium infection of mice, a model of human pathogenic Escheri...

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Identifiers and source

Literature Corpus work: 035a595e-b209-590b-ae79-921149b4827a
DOI: 10.1038/s41396-022-01321-9

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