Article
Inferring bacterial transmission dynamics using deep sequencing genomic surveillance data.
Nature communications - 31 Oct 2023
Senghore Madikay, Read Hannah, Oza Priyali, Johnson Sarah, Passarelli-Araujo Hemanoel, Taylor Bradford P, Ashley Stephen, Grey Alex, Callendrello Alanna, Lee Robyn, Goddard Matthew R, Lumley Thomas, Hanage William P, Wiles Siouxsie
Abstract excerpt
Identifying and interrupting transmission chains is important for controlling infectious diseases. One way to identify transmission pairs - two hosts in which infection was transmitted from one to the other - is using the variation of the pathogen within each single host (within-host variation). However, the role of such variation in transmission is understudied due to a lack of experimental and clinical datasets...
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