Article

Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection

2024-02-23

Abstract excerpt

Noroviruses (NoVs) are a leading cause of viral gastroenteritis. Despite global clinical relevance, our understanding of how host factors, such as antiviral cytokines interferons (IFNs), modulate NoV population dynamics is limited. Murine NoV (MNoV) is a tractable in vivo model for the study of host regulation of NoV. A persistent strain of MNoV, CR6, establishes a reservoir in intestinal tuft cells for chronic v...

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Literature Corpus work: d0f9a3f6-1c00-51c5-8564-e09829bc4a61
DOI: 10.1101/2024.02.22.581634

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